BioTech Intellectual Property

OTC BioTech possesses a rich technology platform that provides a sustainable competitive advantage in that we have pursued intellectual property protection via patent applications. OTC BioTech has been issued 9 U.S. and World patents for key aptamer technology. Two other patents are pending. Together the patent portfolio protects over 3,000 aptamer DNA sequences.

Latest News

March 2011 – OTC Biotech
OTC Biotech is awarded a $730K Phase 2 SBIR from the Dept. of Defense (OSD) entitled “Handheld Aptamer-Magnetic Bead-Quantum Dot Sensor for Leishmania.” Contract No. W81XWH-10-C-0179.
February 2011 – OTC Biotech
OTC Biotech receives a Tibbetts award from the Small Business Administration (SBA) for excellence in aptamer R & D and commercialization potential
February 2011 – OTC Biotech
OTC Biotech is awarded an $80,000 Phase 1 SBIR from the EPA entitled “Handheld FRET-Aptamer Sensor for Chem-Bio Threats.” Contract No. EP-D-11-033.

INTELLECTUAL PROPERTY

Issued Patents

  • 1. Hargreaves K.M., Bruno J.G. Composition of matter (aptamer) that reduces pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof. Filed in conjunction with the Univ. of Texas Health Sciences Center San Antonio, U.S. Patent Application Serial No. 14/029,440. (Notice of Allowance Jan. 6, 2015).
  • 2. Bruno J.G. Methods and Compositions of DNA Ligands for Arthropod-Borne Pathogen Detection and Prophylaxis or Therapy. U.S. Application No. 14/177,962, Publication No. 20140200337. (Notice of Allowance Oct. 28, 2014).
  • 3. Bruno J.G. World Patent: “Methods of producing homogeneous plastic-adherent aptamer-magnetic bead-fluorophore sandwich assays.” WO2009/104075. WIPO/PCT Notice of Allowance July 15, 2014. Corresponding U.S. Patent Application No. 12/378,515 pending (Published March 17, 2011).
  • 4. Bruno J.G. “Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health.” U.S. Patent No. 8,658,613. Issued February 25, 2014.
  • 5. Bruno J.G. “Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy.” U.S. Patent No. 8,648,181. Issued February 11, 2014.
  • 6. Bruno J.G. and Miner J.C. “Therapeutic Nucleic Acid-3'–Conjugates.” U.S. Patent No. 7,910,297, March 22, 2011.
  • 7. Bruno J.G. and Miner J.C. “Therapeutic Nucleic Acid-3'–Conjugates.” U.S. Patent No. 8,318,920, November 27, 2012.
  • 8. Bruno J.G. and Miner J.C. “Therapeutic Nucleic Acid-3'–Conjugates.” U.S. Patent No. 8,389,710, March 5, 2013.
  • 9. Bruno J.G. and Chanpong J.C. “Methods of Producing Intrachain Fluorophore-Quencher FRET-Aptamers and Assays.” U.S. Patent No. 7,906,280, March 15, 2011.

U.S. and World Patent Applications

  • 1. Bruno J.G. Methods and compositions of nucleic acid ligands for detection of foodborne and waterborne pathogens. U.S. Application No. 13/136,820 (Published March 22, 2012).