Applications

OTC Biotechnologies, LLC, (OTC BioTech) is a wholly-owned subsidiary of Operational Technologies Corporation. The OpTech Biotechnology Research Division that later became OTC BioTech was established as a self-supporting R&D activity primarily using funding obtained through the SBIR Program process.

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Publications Using OTC Biotech’s Aptamers

  1. Vance S.A., Sandros M.G. Zeptomole detection of C-Reactive Protein in serum by a nanoparticle amplified surface plasmon resonance imaging Aptasensor. Scientific Reports. 4:5129, 2014. DOI: 10.1038/srep05129.
  2. Queirós R.B., et al. Evanescent wave DNA-aptamer biosensor based on long period gratings for the specific recognition of E. coli outer membrane proteins. Biosensors & Bioelectronics. 62:227-233, 2014.
  3. Queirós R.B., de-los-Santos-Álvarez N, Noronhae JP, Sales MGF. A label-free DNA aptamer-based impedance biosensor for the detection of E. coli outer membrane proteins. Sensors and Actuators B: Chemical. 181:766-772, 2013.
  4. He L., Deen B., Pagel A.H., Diez-Gonzalez F., Labuza T.P. Concentration, detection and discrimination of Bacillus anthracis spores in orange juice using aptamers based surface enhanced Raman spectroscopy. Analyst. 138:1657-1659, 2013. doi: 10.1039/c3an36561a.
  5. Barhona F., Bardliving C., Phifer A., Bruno J.G., Batt C. New aptasensor based on polymer-gold nanoparticles composite microspheres for the detection of malathion using surface-enhanced Raman spectroscopy. Industrial Biotechnology. 9:42-49, 2013. NSF invited article with co-authors from Cornell University.
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  6. Stratis-Cullum D.N., McMasters S., Pellegrino P.M. Evaluation of relative aptamer binding to Campylobacter jejuni bacteria using affinity probe capillary electrophoresis. Analytical Letters, 42: 2389–2402, 2009.

OTC Biotech’s Latest Publications

  1. 1. Bruno J.G., et al. Development of a fluorescent enzyme-linked DNA aptamer-magnetic bead sandwich assay and portable fluorometer for ultrasensitive and rapid Listeria detection. J. Fluorescence. 25:173-183, 2015. PMID: 25511112.
  2. Bruno J.G. Anti-Soman Derivative DNA Aptamers Protect Acetylcholinesterase in Neuro-2a Cells In Vitro. American Journal of Neuroprotection and Neuroregeneration (American Scientific Publishers), 6:43-46, 2014.
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  3. Bruno J.G. Application of DNA Aptamers and Quantum Dots to Lateral Flow Test Strips for Detection of Foodborne Pathogens with Improved Sensitivity versus Colloidal Gold. Pathogens. 3:341-355, 2014.
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Applications

Food, Animal and Water Safety

Food Chain (Farm to Fork Processing)- See Pronucleotein Biotechnologies, an OpTech “spin-out” formed to commercialize assays to detect pathogens and toxins that cause food-borne illness. www.pronucleotein.com

  • Food Freshness (shelf-life and food spoilage indicators)
  • Water/ Beaches Act-Recreational Waters Testing (coliform levels)

Environmental Detection

  • Industrial Water Systems (corrosion markers, bacteria)
  • Chemical Contamination (pesticides)
  • Chem-Bio Warfare Agents (Soman, botulinum toxin, viral hemorrhagic fevers)

Medical and Point of Care Diagnostics

  • Human Health (bone loss markers, cardiovascular markers, vitamin D)
  • Veterinary (foot and mouth disease, anthrax)
  • Pathology (tissue staining, cancer cell markers)
  • Drug Testing (athletics-recombinant human growth hormone)

Medical Therapeutics

  • Human and Veterinary Topical/Parental (MSRA, botulism, parasites, cancer)