Who is Optech Biotech

OTC BioTech conducts research using the biochemical and molecular properties of DNA aptamers and aptamer conjugates to solve unmet health, safety, and social needs.


John G. Bruno, Ph.D.,
Senior Scientist & Chief Technology Officer, has over 25 years of experience in DNA aptamer development, immunology, and microbiology, as well as biological warfare agent, and foodborne and waterborne pathogen detection. He has been highly successful in obtaining federal grants, has authored 58 peer-reviewed research journal articles, two book chapters and an edited book on such diverse topics in molecular recognition as detection of biowarfare agents and E. coli O157:H7 by immunomagnetic-electrochemiluminescence (IM-ECL), detection of toxic metal ions by ligand-capture ECL, and development and use of DNA aptamers for detection of organic pollutants, foodborne pathogens and biowarfare agents. Dr. Bruno also holds six patents.

OTC BioTech


Be an innovative, research center of excellence fully exploiting aptamer and other biological technologies, staffed by committed, highly-qualified scientific experts providing new and better solutions to global clients. Push DNA aptamer-related diagnostic and therapeutic technologies into the marketplace


Conduct focused research to discover and characterize novel aptamers and molecular conjugates that will perform in a specific and consistent manner to solve unmet health, safety, and social challenges resulting in profitable commercial opportunities.

Fact Sheet

OTC Biotech has developed DNA aptamers against a broad array of small molecule and whole cell targets. The highest affinity and most specific aptamers are listed for each category. In some cases binding between the top aptamer choices was virtually identical. Therefore, all of the top aptamer candidates are offered for sale. Researchers are encouraged to purchase and try any or all of the candidate aptamers for their particular applications. Applications can include ELISA-like or “ELASA” assays, aptamer “Western” blotting, and cell or tissue staining. Potential users are encouraged to read the reference list below which contain suggested protocols.

All OTC Biotech DNA Aptamers are available in unmodified form for $200 each (> 1 mg of desalted 55-72 base DNA) with a choice of 5’-primary amine, biotin or fluorescein (FAM) groups for an additional charge of $60. Other custom modifications, fluorophores, or purifications (HPLC or PAGE) are possible, but the customer should call OTC Biotech at 1-800-677-8072 to discuss such modifications. Each aptamer can be rehydrated in standard PBS (pH 7.2-7.4) or other neutral aqueous buffers for use in most applications.