DNA Aptamers

OTC Biotech

OTC Biotech has Developed Numerous Different DNA Aptamers Against Various Pathogenic Bacteria, Viruses, Parasites,Toxins, Clinical Analytes, and Small Molecules which :

Are less expensive than antibodies Have higher affinity than antibody counterparts Often give more specific binding vs. antibodies Give more reproducible results from lot to lot Work well in ELISA, blotting, flow cytometry, IHC and other common immunologic assay formats Common biotin, primary amine and fluorescent dye modifications are available

Shop Aptamers

Advantages of Aptamers :

  • Are less expensive than antibodies
  • Can have higher affinity than antibody counterparts
  • Can provide more specific binding vs. antibodies
  • Provide more reproducible results vs. antibodies from lot-to-lot, because DNA sequences are known and highly reproducible
  • Work well in ELISA, blotting, flow cytometry, IHC, and other common immunologic assay formats
  • Common 5’ biotin, primary amine, and fluorescent dye modifications are available with your order

FACT SHEET

OTC Biotech has developed DNA aptamers against a broad array of small molecule and whole cell targets. The highest affinity and most specific aptamers are listed for each category. In some cases binding between the top aptamer choices was virtually identical. Therefore, all of the top aptamer candidates are offered for sale. Researchers are encouraged to purchase and try any or all of the candidate aptamers for their particular applications. Applications can include ELISA-like or “ELASA” assays, aptamer “Western” blotting, and cell or tissue staining. Potential users are encouraged to read the reference list below which contain suggested protocols.

Most OTC Biotech DNA Aptamers are available in unmodified form for $200 each (> 1 mg of desalted 55-72 base DNA) with a choice of 5’-primary amine, biotin or fluorescein (FAM) groups for an additional charge of $60. Longer (up to 200 base) aptamers cost more as noted on this website. Other custom modifications, fluorophores, or purifications (HPLC or PAGE) are possible, but the customer should call OTC Biotech at 1-800-677-8072 to discuss such modifications. Each aptamer can be rehydrated in standard PBS (pH 7.2-7.4) or other neutral aqueous buffers for use in most applications.

Where are the All Aptamers?

by Geoffery S. Baird, MD, PhD



Univ. of N. Carolina Researchers Use OTC Biotech Aptamer to Achieve Ultrasensitive Zeptomole Level Detection of C-Reactive Protein in Serum.

OTC Biotech Aptamer

Food and Waterborne Pathogens and Toxins

Food and Waterborne Pathogens and Toxins

Includes Aptamers that bind Bacillus endospores, Campylobacter, pathogenic E. coli, Listeria, Salmonella, and Shiga toxins

Parasites

Parasites

Includes Aptamers that bind Leishmania, Chikungunya, Crimean-Congo, Dengue, West Nile Virus, Rickettsia, and TBEV

Viruses

Viruses

Includes Aptamers that bind Leishmania, Chikungunya, Crimean-Congo, Dengue, West Nile Virus, Rickettsia, and TBEV

Clinical Analytes and Small Molecules

Clinical Analytes and Small Molecules

Includes Aptamers that bind bone and cardiovascular markers, human growth hormone, Interleukins 6 and 18, acetylcholine

Order Information

Interested customers can call OTC Biotech (1-800-677-8072) to discuss custom aptamer development against targets of their choice.

Email Contact : sales@otcbiotech.com